Tag Archives: #Genetics

Saintcrow, L. (2016). Cormorant Run. New York: Orbit.

Cover design by Lauren Panepinto. Cover illustration by Kirbi Fagan.

STRUGOVSKY: All we can say for certain is that one night, eighty-six years ago, there were strange lights in the skies of many countries. Aurora borealis, perhaps. Then, the Event, at a very specific time….

… Rifts, are actually tears in a fabric we cannot adequately measure. It is not Einstein’s spacetime, it is not Hawking’s and Velikov’s layer cake, it is not the Ptolemaic bubbles of earth and air. When we know what fabric is being so roughly torn, we may begin to reclaim those parts of the Earth’s surface. (Kindle Loc. 125-135).

When rift bubbles appeared the world fell apart. Whole cities disappeared. If a bubble landed in a city, what was inside (even moving things) was lost to the rest of the world. People on the outside could only see a slow-moving opalescent sheen. Railroad tracks could run right through the rift-walls but what happened to the tracks on the inside no one but rifters knew.  Most of the people (military/researchers) who went inside to see what had happened disappeared, probably dead.

Rifters are people of high intelligence who survive running the rift bubbles but come out changed. Either a wanna-be rifter learns how to be still, to quickly analyse their environment, to plan and execute quickly, to test the ground for stability, to be patience, or they died. They developed an acute sense of smell and hearing. Addicted to rifting and different from non-rifters, most of them are underestimated.

The gleaming inside the shattered leav was skeletons, turned into some sort of alloy. It took two weeks of patient work by teams in magsuits to free them from the tangle, and they were carted away to the depths of the Institute. Someone did a hush-hush paper on them—the bones were alloy, where the ligaments were all high-carbon flex with an odd crystalline pattern all over. (Kindle loc 194-196).

Institutes were set up outside the bubbles filled with people wanting to study them. Most of the researchers who went inside never returned. Then the Crash happened. Eventually kill-zones and garrisons were set up outside the bubbles to keep the things inside from coming out and the curious from entering.

There, at the very edge of her vision, a shimmering. Light bouncing in weird ways, and the space inside her empty-aching like a pulled tooth. (Kindle Loc 233-234).

Asje Rajtnik (Rat) died as a result of not being listened to.  QR-715 takes exception to such stupidity and punishes it accordingly. After the attempt, the result was a “shoot on sight” order. However, greed is not always sensible and, one year later, 33-year old Tatiana Pajari, better known as “Svinga” or “Svin”, is taken from solitary in Guan prison to QR-715. Her two year stay in solitary darkness has left her underweight, sickly pale and traumatized. Svin has been a rifter since she was 16 and Kopeland wants because she was apprenticed to Rat. From the first moment in the leav I liked her and that like grew during the story. She is clearly a traumatized person who is making the best of this situation she suspects she is not intended to survive.

Kommandant Kopeland is a frustrated person. He is stuck as top of a local governmental installation and knows he will not advance. Being close to QR-715 tends to make people afraid and bored over time. Plus he is a bully. Combined with his boredom and his fears he becomes obsessed with acquiring the Cormorant and sees it as a way out. So, he has Svin brought to him.

QR-715 is our third main character. Its size makes it unique and full of weird fauna and flora. Geography moves around, gravity and mass changes and time is difficult to nail down. One moment you might die if you step off a ledge, the next you’ll be fine. As we get to know it, QR-715 feels intelligent and alive. And weird, really weird.

Saintcrow’s POV moved between various actors in the story.  Svin, Kopeland and QR-715 were the characters that were brought to life. The rest functioned more as supporting characters. At certain points the many POV’s hiccuped the flow of the story.

There are foot-notes that explain terminology. In my Kindle edition I pressed the highlighted sign and a definition popped up. In the paper edition, it looks like the footnotes are at the bottom of the page. Foot-notes work well for me and seldom mess up the flow, but they might a problem for others. General editing seemed fine. Saintcrow fed us information about the history of the Event and how the world turned out in bits and pieces throughout the story. That is my preferred method of getting to know the landscape.

I really liked Cormorant Run. Most of the people in it were just people. Blind, stupid, thoughtful, afraid, greedy, eager, sociopathic, kind and vengeful. You know, people. What it is not, is a story with a “happy ending”. Saintcrow seldom does those. While reading it, I sometimes felt the way I do when I read some of Philip Dick’s stories – “huh?”. I recommend this story to people who like science fiction weirdness. There is plenty of violence and swearing but Zero romance (YEAH!!!!).


Reviews:

Gorman, K.; Black Dawn (Eurynome Code 1)(2017)

Karin Makos has a secret she wants to keep under wraps. Her sister knows about it. After all, Nomiki was another child experimented on. In Black Dawn, Karin is our protagonist. We get to know her sister through Karin’s dreams. Black Dawn is told from a third-person perspective as seen from Karin’s point of view and everything we find out about her universe is what Karin experiences and thinks.

Karin, Marc and Soo-Jin  are scavengers, travelling in the Nemina, chasing First Gen Earth objects – like beer cans. They travel to abandoned sites/worlds to find goods and sell them on to collectors. Karin is the overqualified pilot, Marc owns the Nemina and Soo-Jin is their First-Gen specialist and marketer. They are both Karin’s side-kicks and play vital seconds to her in different episodes of this novel. Karin is the only three-dimensional character.

After a successful run someone enters their space ship and attacks all three while they sleep. Abruptly waking from a dream …

She sucked in a breath.

It was a man – or, at the very least, a very life-like, man-shaped shadow. Tall, with edges that blended into the room’s already significant darkness, he stood against the wall with no definition to him, only darkness. she couldn’t see any features, not eyes or the rumples where clothes might be, or – heck, were those arms?

Karin is forced to use her special ability or die. An ability that becomes more and more difficult to hide as the story progresses.

Light pricked through the blackness. The white droplets on her arm still shone, dimmer than before, but persistent.

She brought her hand up. Muscles shaking, she pushed energy into the light. It shivered at her touch like water under a full moon, waxing, growing. The thing’s hand moved into her eyes. A fingertip brushed through her skull like the touch of a feather. She cringed, pulled away. Then she pushed back.

Light exploded from her skin.

The black think shrieked.

Karin confronts her dilemma many times during Black Dawn. To use or not to use. She knows what to expect if people find out about her ability, yet it may be that her ability can save people from the effects of the Shadow people. Few individuals find themselves with both a talent that might save many along with a tendency to freeze in dangerous situations. Karin does. If she had been all alone in the situations in Black Dawn, the novel would have ended much sooner. However, our shero works hard to control her panic attacks and manages to pull through each time.  Black Dawn might be about learning to trust yourself and others. It’s also about needing to use gifts/talents if you want them to grow and about trying to not let past decisions rule current ones.

We find out about Karin’s background and genetic modification as the story develops. Even though it is a serial, the Black Dawn ends at a good spot rather than in the middle of a climax. The story is a science fiction space opera low on technology but high on action/drama/adventure. There is no graphic violence or  sexual content. I liked the prose and do not think I have come across plots with Shadows attackers in them. This was an entertaining story that is the first of a trilogy. Recommended.

Farrugia, Nathan M; Exclave (Helix VI); 2017

When we last left Sophia, unfriendlies came to visit.

She deposited her empty glass beside Aviary’s phone on the coffee table. The phone flashed.

Infrared cameras.

Stingball grenades hit the floor. Everyone dropped their drinks and scattered. The grenades detonated, deafeningly loud, blasting the nearby windows into pieces.

Everything around Sophia turned white.

Enclave begins with Hal’s point of view of the attack. He is not, at all, happy with Sophia and her people and is set on destroying them. Except things aren’t really going his way lately. His one goal in life is to capture Sophia alive and kill the rest of the members of her crew.

There are some seriously messed up people in Farrugia’s world and many of them hide behind the cover Purity.  Purity is anti-genetic tinkering (except the kind they approve of) and as with many ideologies most of the grunts in Purity want to believe its  propaganda while the higher-ups are in it for other reasons. Once propaganda gets a hold it is difficult to fight and keep from spreading. Lithuania’s border guards have started testing people for genetic tinkering making it too dangerous for people with specific genetic tags.

Sophia needs a new safe-house and Olesya brings Sophia and her crew with her back to the enclave in Kaliningrad in Russia. When she gets there she finds out that Illarion is leaving her in charge of the enclave. To top it all, Olesya discovers there is a mole in their midst. It might be fair to say that things aren’t really going very well for any of our players, except for Purity. Or are they?

Nathan M. Farrugia writes the serial Helix. So far, it consists of six episodes (see links to reviews below), each the size of a novellas, each ending with cliff-hangers.  Three of these episodes together consist of around 7000 words. Farrugia had to crowd-fund Enclave and will probably have to do the same for the remaining three episodes. Due to his background and interests, Farrugia makes his specialist soldiers believable and that goes for the technology as well. Enclave is a fast-paced cyberpunk thriller with lots of fighting and stunts. Crazy stunts that require the regenerative genes of the gang.

The author gave me a copy of Exclave. Update 13.03.3018. I later bought my own copy. I have changed the review a bit.


Reviews:


My reviews of:

  1. Helix Episode 1
  2. Helix Episode 2 (Exile)
  3. Helix Episode 3 (Interceptor)
  4. Helix Episode 4 (Anomaly)
  5. Helix Episode 5 (Inversion)

Farrugia, Nathan M.; Inversion (Helix V)(2016)

Farrugia‘s Sophia and Olesya serials have forced me to reevaluate some of my preconceptions, stereotypes or prejudices. Thrillers are meant to keep us at the edge of our seat until some sort of climax occurs. Farrugia’s episodes have brought us threats to humanity, political entities and various teams. His “super-heroes” are Olesya and Sophia, and their various team-members have had their spot in the lime-light. Like all thriller-heroes, Olesya, Sophia and their team-members survive when they, logically, should not. My Aspie demands that I check out what exists and what does not, i.e. stun-net-guns with adhesive qualities. I can lay that aside, because an excellent thriller needs to stretch our sense of logic but not completely break it. Or, at least, that is my judgement of an excellent thriller. Inversion proves, once more, what an excellent writer Farrugia is.

An excellent thriller also needs convince us that their plot could happen in real life. Authors who are not willing to sacrifice their writing to tighten up their plots, research their material and have writing in their blood, never reach that point. Farrugia does.

Inversion brings us to Wrocław, Poland and once again to Purity.

“But how do they frame Russia if everyone’s dead?” Aviary asked.

“Exactly,” Sophia said. “The world will be furious. And in their fury, they’ll support Purity.”

Consider Poland’s Jarosław Kaczyński’s methods:

…Law and Justice party has continued to depict the accident as an assassination of its leader, with blame shared by the usual villainous alliance of liberals and communists….

Poland’s present turmoil is the story of how anger at Poland’s liberals mutated into a war on liberal democracy itself. (The Guardian)

A thriller also needs to mess with our minds. In the Sophia and Olesya serials we do not know who the real powers are. I have made guesses in all of my previous reviews, and some of those guesses now seem wrong. Part of that has to do with the long lives of those who are behind the messes of Farrugia’s world. We have been told, through Major Sievers, Hal and Denton, that there are some seriously powerful people behind what is going on. But I have no idea how interlinked the various groups are.

This time around, the people behind Purity use a celebratory march in Wrocław as a lure for Aviary, and, through her, the Russian Directorate. Purity needs a big, bad bear to blame for what is about to happen. The people behind Purity control elements of The Fifth Column, the leadership of Purity and JW GROM (Poland’s antiterrorism unit).

Intron’s Hélio does not trust the documentation Doctor Meresz shared about the kill-switch. As we saw in Anomaly, that is a good thing. Hélio wants to stay with Sophia until he has run some tests on her theories. He and his body guards go with the team to Wrocław. Whether they are trustworthy is debatable. That depends on Intron’s agenda.

Inversion shows us how little control Sophia and Olesya actually have. Their choices depend on Aviary’s findings and those findings are the result of people who know what will trigger both team-leaders, and especially Sophia.

“… she won’t rest until she rights her wrongs.” He stared at the trashcan. “Even then, I don’t think she’ll stop.”

Besides wanting to know who the people behind these groups are, I really want to know how DC knew how to turn up where he did when he did. And what about that gunship? Who do the cloaked ones belong to? Oh, and when you go into a fight, don’t partner with a person your are falling in love with. Losing focus on the roofs around the market place is seriously dangerous to your health. Try to remember that the next time you go to Wrocław in Poland. And do those bobby pins mean anything? Please, I need to know.

Definitely recommended.

I received a complimentary copy of Inversion from Farrugia


Reviews:


My reviews of:

  1. Helix I (Olesya and Sophia)
  2. Exile (Helix II)
  3. Interceptor (Helix III)
  4. Anomaly (Helix IV)
  5. The Chimera Vector (Sophia)
  6. Seraphim Sequence (Sophia II)
  7. Phoenix Variant (Sophia III)

Inversion can be bought at Amazon.com

 

Farrugia, Nathan; Anomaly (Helix IV) (2016)

Sophia portrayed by Haylee Collins / Photographer: Andrew Maccoll / Cover design: Pat Naoum
Sophia portrayed by Haylee Collins / Photographer: Andrew Maccoll / Cover design: Pat Naoum

Sometimes getting to know the author is as fun as getting to know the characters. Farrugia is probably as adrenaline addicted as Sophia but, thankfully, seems a ways off Denton’s brand of crazy. He is also funny as hell and a great writer.

This odd group of animals I belong to, seems hell-bent on destroying itself in one way or another. Often, I wonder who profits from the unrest going on. Seeing behind propaganda, to the Dentons, Hals and Sievers of this world, takes time and effort. What Farrugia manages to get across in Anomaly is how little the pawns, even at the level of Illarion, know. Just because two parties kill each-other, doesn’t mean they oppose each other. Unlike many of the real-world conspiracies I hear/read, Farrugia’s conspiracy thriller shows us a believable chess-game where the consequences to the players are small, but to their pawns, well.

Purity is clearly one of the pawns being played. We got an inkling of that in Interceptor. Anomaly‘s use of Hal, Denton and DC pushes me to think in one direction. Farrugia is probably just messing with my mind. Cults are terrifying creatures. Especially political cults. Nazism was one. We see another one tear its way through Europe, triggered by the 70-year-long battle between USA and Russia that is, at this part of the “game”, destroying the Middle-East. Purity has reached the point of the mob. “Burn the witches” is a chant at one of their rallies. Farrugia paints the mindlessness, hysterical anger, fear and violence present in such a mob perfectly.

We get to know Marina better. I find myself curious about her. “Will this hurt?” she asked. And it did. It takes a special kind of training to acquire the mind-set of the researchers in the various Columns, training most people would pass.

Eastern Europe is clearly in trouble and the only ones who might save it are Sophia and Olesya’s people. But only if the two groups cooperate. Both feel the need to talk but are afraid to trust the other. They know that no matter what they choose, the likelihood of their groups getting out intact is nil. However, both are the kind of leader who wants to get as much of her team out alive and as well as possible.

What on earth are Intron’s goals? They aren’t what Hélio  says. Why are Fifth Column’s implants turning up in such strange people? Who are training these new, indestructible operatives? What is DC up to? How are Purity identifying the mutants? Can paranoia be taken too far?

As usual, I had fun. Lots of action, lots of conspiracy and one hell of a mystery. Definitely recommended.

I was given an advance copy of Anomaly to review.


Reviews:


My reviews of:

  1. Helix
  2. Exile
  3. Interceptor

Anomaly is available at Amazon

Farrugia, Nathan; Interceptor (Helix III) (2016)

Helix 3 - Interceptor cover

Sievers turned his lapel out so Denton could see him reaching for a small, slender tin. He crouched and opened the tin on the floorboards, then stepped back. Inside, a large stainless steel and glass syringe. The liquid inside the syringe burned with the colors of molten lava.

“You already know what this is,” Sievers said. “And you’ll need it, if you intend to live long enough to find what you’re really looking for.”

Denton took a step toward him. “You’re using my people to get what you want.”

For the first time, Sievers smiled. White teeth flashed between his black beard. “And you are doing precisely the same.”

Colonel Wolfram Sievers and Lieutenant Denton have lived a long time. Both are willing to go to extreme lengths to achieve what they want. For Denton that seems to be world domination through Project Gate. Sievers appears to be playing another game. That game could be called chaos. Peace would probably be boring business for his superiors. Obvious suspects for such superiors might be arms manufacturers who may or may not work with biological/genetic research firms like Intero. As far as I can tell, the various countries (certainly many politicians) in the Helix world (and real) are simply pawns in the hands of these entities.

As I have said in previous reviews, one of the major appeals of Farrugia‘s stories is that they could happen. Reactions of the general populace would probably (and do) fit his description of the election of the Purity party’s leadership into Poland’s government. Fear of people with genetic mutations is increasing among the population, thereby legitimizing the Purists going after our “heroes” with the aim of targeting/turning off their mutations.

In Exile, Sophia met an operative from the Fifth Column who self-destructed when Sophia attempted to de-program her. This time around, she meets a completely different type of agent. Who or what these new operatives belong to becomes a pressing question. So does the question of DC’s loyalties. Will Jay, Nasira, Damien and Aviary be able to infiltrate Intero’s data system and what about finding Val. How is that going for Olesya and her team? And who the hell are the Benefactors?

From the various links, you would be correct in presuming I had fun with Interceptor. There is so much going on, I cannot help but dig. At the same time, I do have to stop digging and write a review. Once again, definitely recommended.


Farrugia provided me with a reviewer’s copy of Interceptor.


Interceptor is available at Amazon


My reviews of:

  1. Helix Episode I
  2. Exile (Helix II)
  3. The Chimera Vector (Sophia)
  4. Seraphim Sequence (Sophia II)
  5. Phoenix Variant (Sophia III)

Farrugia, Nathan; Exile (Helix II) (2016)

Helix - Episode 2
Photo by Andrew Maccoll, Cover design by Pat Naoum

Nathan. You cretin.  If telepathic strangling had been possible, I might have given it a try all the way from Norway. Cliff-hangers like this should be forbidden.

History repeats itself over and over and over again. Using The Fifth Column as his title for the Sophia series, and inserting Sixth Column as rebels to the usurper group, shows us how we continue to live in repetition. The tool used by any power, be it national or institutional, to get the public to go along with it is two-fold: propaganda (mild brainwashing) and force. In the Fifth Column trilogy, Denton and McLoughlin used both to get a strong hold on US military, US government and US public. Propaganda uses less blood and is often (usually) difficult to see through.

I am 51 years old and have been through all sorts of propaganda periods. Usually, I like to think of myself as a feminist. In Exile, Nathan showed me how far I have left to go.

Damien, Jay and Nasira have gone to Las Vegas to get hold of Aviary (from The Fifth Column). Since Jay has lost his genetic advantages, and is still healing from the killing shots from Helix I, he is get-away driver. Nasira and Damien want to rescue Aviary and have to get through a group of Marines guarding her room. Nasira begins the fight and Damien joins in.

“That would be my cue, Damien thought.

He launched for the marine behind him, grasped the barrel of her gun and twisted it up, tangling her trigger finger. The scope broke her nose, blood spattering the door of the room.”

I was completely surprised when the marine was a woman. So much for my feminism. But that is the power of propaganda. Farrugia just dump women and men into situations without regard for gender and lets them do their thing. And that is incredibly cool and hopeful.

There are three main groups in Exile. The first is the above. Their self-imposed job is to find Aviary and get her to help them again. The above shows one of the complications that arise.

Our second group is Olesya and Ark(adiy) and their masters. Val was taken by Intron Genetics Incorporated operators towards the end of Helix I. She was the third operative taken that week. They are not the only three who have been kidnapped. The loss of Ark’s sister hit both of them hard, and they desperately want her back. But Illarion does not agree with their assessment of Intron’s involvement. So he sends them to Poland due to an apparent shift of Fifth Column operatives to Eastern Europe and the loss of several hunters in the area. Something major seems to be going down.

The third group is Sophia, Czarina and Ieva. Sophia rescued and deprogrammed both of them. At this point she was teaching them to deprogram others. That is Sophia’s main mission (much as it is Olesya’s), to catch and deprogram Fifth Column operatives. However, catching people who fight for their lives is not a simple matter. At least Sophia has access to the location of every live Fifth Column operative.

Finally, there is the matter of Denton and Loughlin’s goal of making impossible-to-catch operatives. These two are extremely driven people who will do absolutely anything to accomplish their goals and retain their positions. That includes operators like Priya, who Sophia stumbles across on one of her jobs to save people from the clutches of the Fifth Column.

Well written as usual. Fun and believable fighting. Plenty of intrigue. Farrugia does techno-thrillers well. Definitely recommended.


Exile: Helix II is available on Amazon US


My review of Helix: Episode I


An ARC of Exile (Helix II) was given to me by the author


Intron:

Introns are present in the initial RNA transcript, known as pre-mRNA. They need to be removed in order for the mRNA to be able to direct the production of proteins. Pre-mRNA, therefore, undergoes a process, known as splicing, to create mature mRNA. (6, 8)

It is vital for the introns to be removed precisely, as any left-over intron nucleotides, or deletion of exon nucleotides, may result in a faulty protein being produced. This is because the amino acids that make up proteins are joined together based on codons, which consist of three nucleotides. An imprecise intron removal thus may result in a frameshift, which means that the genetic code would be read incorrectly. (3)

This can be explained by using the following phrase as a metaphor for an exon: “BOB THE BIG TAN CAT”. If the intron before this exon was imprecisely removed, so that the “B” was no longer present, then the sequence would become unreadable: “OBT HEB IGT ANC AT…”